Water-18O to produce 18FDG for PET applications

Positron Emission Tomography (PET) is a nuclear medicine medical imaging technique where radioactive 'tracer' isotopes which emit a positron are injected into a living subject (usually blood circuit). After traveling less than one millimeter the positron annihilates with an electron, producing a pair of gamma ray photons in opposite directions. The technique depends on simultaneous or "coincidental" detection of this pair of photons: photons which do not come in pairs (within a few nanoseconds) are ignored. By measuring where the gamma rays end up, their origin in the body can be plotted, allowing the chemical uptake or activity of certain part of the body to be determined. It is used heavily in clinical oncology (medical imaging of tumors and search for metastases) and in human brain and heart research.

Radionuclides used in PET scanning are typically isotopes with short half lives such as Carbon-11, Nitrogen-13, Oxygen-15, and Fluorine-18. Due to their short half-lives, the isotopes must be produced in a cyclotron at or near the site of the PET scanner. These isotopes are incorporated into compounds normally used by the body such as glucose, water or ammonia and then injected into the body to trace where they become distributed.

Guaranteed high quality based on GMP
18O is manufactured according to GMP-based production & quality control.
Sterility and purity are strictly controlled throughout the manufacturing process.
The product is bottled in Class 100 clean benches followed by autoclave sterilization at 121
oC for 20 minutes.

Read more about the manufacturing process and quality control water 18O. Click here for document.

98atom% Enrichment
A High Purity Solution

PET using [18F]FDG is the most advanced technology for the detection of cancer. Taiyo Nippon Sanso Corporation has chosen Scopus Research to distribute their enriched water product.

18O2 separation plant

Taiyo Nippon Sanso has developed a high-quality Water-18O ((H218O) cyclotron target for FDG-PET using cryogenically distilled ultra-pure oxygen.
The Cyclotron
A cyclotron is a machine to accelerate beams of charged particles by using a high frequency alternating voltage across a magnetic field to spiral the beam out and eventually deflect it once the beam's radius equals its container's. At this point the particles' speed is generally very high, approaching the speed of light. The cyclotron was invented by Ernest Lawrence in 1929, who used it in experiments which required particles of speeds of up to 1 MeV. Cyclotrons are used today in the treatment of cancer, as the particles produced ionize tumors and help to stop or slow cancerous growth.